• Affecting approximately million people worldwide

  2018-10-25

  

  Affecting approximately 30 million people worldwide, Alzheimer\'s disease (AD) is the most common cause of dementia and there is no cure. The cost to the American public for treating AD is currently estimated at $214 billion per year, a concerning statistic given that the disease population is expec

• In vitro high concentrations of palmitate

  2018-10-25

  

  In vitro, high concentrations of palmitate, glucose, or both combined cause beta cell endoplasmic reticulum (ER) stress and apoptosis. Beta cell ER stress is a known feature of type 2 diabetes in humans and animal models (). Cells respond to ER stress by activating the unfolded protein response (UPR

• integrin inhibitors br Author Contributions br Conflict of I

  2018-10-25

  

  Author Contributions Conflict of Interest Acknowledgments We thank Dr. Jennifer Darnell for valuable comments, Dr. Maurice Swanson for the mice, Matthew Bancone for assistance with muscle fiber CSA assessment and Dr. Glenn Morris, Dr. Ian Holt and the Muscular Dystrophy Association Monoclo

• br Author contributions br Declaration of interests br Ackno

  2018-10-25

  

  Author contributions Declaration of interests Acknowledgements This publication made use of the Neisseria Multi Locus Sequence Typing website (http://pubmlst.org/neisseria/) developed by Keith Jolley and sited at the University of Oxford (Jolley and Maiden, 2010). The development of this

• angiotensin receptor blockers The baseline characteristics o

  2018-10-25

  

  The baseline characteristics of both groups were almost comparable (Table 1.). The vRVR rates and the SVR12 rates calculated per each intention-to-treat (ITT) population and for those who completed the full protocol (PP) in each group are presented in (Table 2). The vRVR rates showed no statistica

• Kinematic data were low pass filtered

  2018-10-25

  

  Kinematic data were low-pass filtered (15Hz cutoff; Matlab R2012a), ground reaction force data were low-pass filtered (50Hz cutoff), and internal joint moments were computed using matched filter cutoffs (15Hz). EMG data were band pass filtered (15–300Hz cutoff), full-wave rectified, and low-pass fil

• where is the set of all subjects is the

  2018-10-25

  

  where is the set of all subjects, is the set of all raters, is the lesion mask from rater r, is the lesion mask for the algorithm A, and Corr is the Pearson׳s correlation coefficient of the volumes. This is then linearly normalized by the inter-rater scores between each rater such that the lower

• Technological innovation is an essential driver

  2018-10-25

  

  Technological innovation is an essential driver of human and economic development. It can improve the functioning of markets (), promote government accountability (), build human capital (), and reduce the risks we face from global environmental change (). Yet designing technologies that improve the

• Adolescents in this study averaged over h

  2018-10-25

  

  Adolescents in this study averaged over 8h of sleep per night, which is similar to what has been obtained in other studies with this age group (Wolfson and Carskadon, 1998; Fuligni and Hardway, 2006) and is close to the number of hours recommended for adolescents (Wolfson and Carskadon, 1998). Yet,

• cerk An important fact for memory development

  2018-10-25

  

  An important fact for memory development is that some of the MTL circuitry has a protracted period of development, with the functions of the PRC developing early, CA1 volumes developing substantially over the first two years, albeit at different rates based on layer input origination, and CA3 and th

• In sum understanding more precisely how mindsets relate to t

  2018-10-25

  

  In sum, understanding more precisely how mindsets relate to the processes that occur immediately after mistakes in this norepinephrine bitartrate manufacturer younger age range may open novel avenues for research and intervention to improve resilience. Thus, in the current study, school-age childre

• br Methods of survey data collection and analysis br

  2018-10-25

  

  Methods of survey, data collection and analysis Conflict of Interest Acknowledgements Data Data provided in this article correspond to the FASTQ files obtained after RNA sequencing of melanoma receptor tyrosine kinase from two mouse models, treated with scramble shRNA or Rack1-targeting

• Our patient had skin M

  2018-10-25

  

  Our patient had skin M intracellulare infections involving different skin areas within a short period. In view of the simultaneous occurrence of multiple lesions and the absence of related local skin trauma histories, we suspected that his skin infections might result from a hematogenous or lymphati

• br Mechanism of the regulation of

  2018-10-25

  

  Mechanism of the regulation of melanocyte function by keratinocytes To understand the mechanism of the regulation of melanocyte function by keratinocytes, analysis by a co-culture system of melanocytes and keratinocytes is useful. For the co-culture of melanocytes and keratinocytes, pure culture

• La manera en que se habla del Mercado suele

  2018-10-25

  

  La manera en que se habla del Mercado suele ser muy economicista, pero las economistas feministas están ampliando la perspectiva de análisis, al subrayar que el Mercado no solo desata procesos económicos, sino que también da forma tsa hdac la cultura y a la política. La economía feminista plantea qu

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