• Prednisone prephase was initiated and

  2019-05-30

  

  Prednisone prephase was initiated and led to immediate improvement of clinical status. However, tumour size did not decrease within the prolonged prephase of 11 days (Fig. 1b). Despite additional cyclophosphamide (2×200mg/m2), the patient showed deteriorating clinical condition and fever reappeared

• Treatment options for elderly AML must be based on

  2019-05-30

  

  Treatment options for elderly AML must be based on four main factors: patient\'s clinical condition, disease characteristics, patient wishes and social support. Thus, the most frail and oldest among the oldest will have the least net benefit from chemotherapy or hematopoietic transplantation, even i

• In patients with systolic heart

  2019-05-30

  

  In patients with systolic heart failure and a wide QRS complex, cardiac resynchronisation therapy (CRT) using left ventricular (LV) pacing has been shown to enhance survival, reduce heart failure hospitalisation and enhance exercise capacity in patients with all agomelatine of heart failure. The pa

• Patients with heart failure are at a high risk

  2019-05-30

  

  Patients with heart failure are at a high risk of mortality and morbidity. Medical expenses associated with heart failure are increasing, and approaches aimed at early heart failure detection and reduction of the hospitalization rate are yet to be developed. Patients with CIEDs also develop heart fa

• Several mechanisms for cardiac involvement have

  2019-05-30

  

  Several mechanisms for cardiac involvement have been propounded as (1) direct cardiac involvement, (2) hematogenous spread, (3) lymphatic spread, (4) spreading from the venous system, such as the pulmonary vein or inferior vena cava. In cases of pericardium metastasis, most spreading routes result f

• The re treatment of metastatic

  2019-05-30

  

  The re-treatment of metastatic bone disease causing recurrent pain after an initial course of EBRT was seen to be feasible with a reasonable rate of symptom relief [13–19]. In echoing the ACR findings, the task force noted that the available data was derived from studies where re-treatment was not t

• br Discussion and outstanding questions Reproductive endocri

  2019-05-30

  

  Discussion and outstanding questions Reproductive endocrine hormones such as inhibin affect breast cancer cell survival in the primary tumour and affect tumour homing and survival in the bone microenvironment. The molecular mechanism driving this effect of hormones in bone is likely to be multifa

• br Materials and methods Fifteen healthy adult men participa

  2019-05-30

  

  Materials and methods Fifteen healthy adult men participated in this study. The left anterior chest area was subdivided into 15 regions based on 5 longitudinal points (from the second to the sixth intercostal spaces) and 3 lateral points (including the left sternal border, midclavicular line, and

• In the univariate subgroup analysis the factors that predict

  2019-05-30

  

  In the univariate subgroup analysis, the factors that predicted reduced survival were increased age, significant mitral regurgitation (≥ grade 2), and creatinine level (Table 4). After multivariate analysis, (+)PES followed by ICD btk inhibitor was a strong predictor of reduced mortality, along wit

• Concern about the effects on health of chemical exposure to

  2019-05-30

  

  Concern about the effects on health of chemical exposure to e-waste and e-waste recycling is increasing despite the paucity of solid research. Reported adverse effects include: fetal loss, prematurity, low birthweight, and congenital malformations; abnormal thyroid function and thyroid development;

• In the context of cataract

  2019-05-30

  

  In the context of cataract surgery, Nathan Congdon and colleagues (August, p e37) propose the possibility of using early postoperative assessment of all patients or late assessment only of those who return for follow-up without additional prompting as practicable methods to improve long-term patient

• is a fastidious organism requiring

  2019-05-30

  

  is a fastidious organism requiring specific nutritional, atmospheric, and temperature requirements for growth. For this reason culture capability might only be available in limited PICT microbiology laboratories. The use of multiplex PCR targeting common pathogens associated with genital ulceration

• br There is growing recognition that children

  2019-05-30

  

  There is growing recognition that children bear a substantial burden of tuberculosis morbidity and mortality. However, in regions where the diagnosis is contingent on smear microscopy, the burden attributable to children, who usually have paucibacillary disease, is grossly underestimated. The down

• It means an opportunity As we concern ourselves

  2019-05-30

  

  It means an opportunity. As we concern ourselves with the prominence of health in the new agenda, it\'s easy to forget that (human) development is by definition people-centred, and that living a long, healthy, and creative life is its cornerstone. The expansion of the new goals to encompass many (if

• Table shows the AF ablation procedure data The preoperative

  2019-05-29

  

  Table 2 shows the AF ablation procedure data. The preoperative inspection consisted of transesophageal echocardiography and cardiac computed tomography (CT) in 79.9% and 80.8%, respectively; cardiac magnetic resonance imaging (MRI) was performed in only 1.1% of the patients. Two 3D mapping systems w

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