• phenylephrine hydrochloride In this work we fabricated a kin

  2020-11-27

  

  In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic phenylephrine hydrochloride copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsul

• br Conclusions We can conclude that Arg is

  2020-11-27

  

  Conclusions We can conclude that Arg293 is important but not indispensable for MeGlcA recognition by EcXyn30A since the R293A variant still retains activity and preference for MeGlcA-substituted substrates. The substrate specificity of GH30_8 glucuronoxylanases is most probably determined by an o

• Within the X CX PX RX

  2020-11-27

  

  Within the X1CX3PX5RX7 motif of several prokaryotic FGE substrates, the residues of X3, X5, and X7 are variably found as mixtures of alanine, glycine, threonine, or serine residues [26], [27]. The docked model of our identified HCTPRRP motif revealed that position X1 (H1) and position X7 (P7) were n

• The activity of cysteine endopeptidases involved in

  2020-11-27

  

  The activity of cysteine endopeptidases involved in the germination of caryopses is generally regulated at two levels: the hormonal induction of synthesis by gibberellins (Drzymała et al., 2008) and a putative regulation of activity by phytocystatines (Kiyosaki et al., 2007, Martinez et al., 2009),

• Previous studies in the Swiss Webster

  2020-11-27

  

  Previous studies in the Swiss Webster mouse (Rosengren et al., 1995) and the Sprague–Dawley rat (El Sisi et al., 1993) have shown that retinol pretreatment potentiates the hepatotoxicity of paracetamol. The current study is designed to investigate further this interaction in mice. To accomplish this

• Because of the important role of the DDB CUL

  2020-11-27

  

  Because of the important role of the DDB1-CUL4B interaction for CUL4B-based E3 ligases, disruption of the DDB1-CUL4B interaction could be an effective approach to treat cancer. Therefore, we developed an in vitro HTS assay based on yeast cell growth inhibition to identify compounds that could disrup

• Several functions of FAT have been suggested It has

  2020-11-27

  

  Several functions of FAT10 have been suggested. It has been shown that FAT10 binds noncovalently to the mitotic spindle checkpoint protein MAD2 and that this binding might cause chromosome instability in the cancer MRS 2365 overexpressing FAT10 (Liu et al., 1999, Ren et al., 2006). In other studies

• Most enzymes involved in the addition and removal of

  2020-11-27

  

  Most corticosterone involved in the addition and removal of ubiquitin bind weakly to an overlapping surface on ubiquitin. Previously, Sidhu and colleagues diversified this surface and then used phage display to screen these libraries of ubiquitin variants (UbVs) for binding to DUBs and E3 ligases (E

• In conclusion we have found that Egr can play

  2020-11-27

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response 2076 at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH promoter. We specula

• The first ones class A receptors

  2020-11-27

  

  The first ones class A receptors found as heterodimers were reported by Gomes et al. (2000), who identified a heteromer constituted by two subtypes of opioid receptors (μ and δ) in heterologous cells. The same year, Ginés et al. (2000) showed the first heteromer composed of two different receptors,

• Additional derivatives were synthesised using a modified app

  2020-11-27

  

  Additional derivatives were synthesised using a modified approach (). Commercially available 4-bromo-2-methoxyaniline () was converted into the boronic ester , followed by a Suzuki–Miyaura cross-coupling with chromenone triflate to afford the corresponding arylamine . Acylation of with chloroacetyl

• br Conclusion The present work describes the

  2020-11-27

  

  Conclusion The present work describes the synthesis of 18 naphthoquinonolyl-1,2,3-triazole compounds based on natural product modification with antiplasmodial activity. Lapachol derivatives disclosed higher activity than the natural product. Six of these final modified lapachol 1,2,3-triazole com

• br Conclusions In conclusion we

  2020-11-26

  

  Conclusions In conclusion, we identified and overexpressed DGAT2 in fast growing, oleaginous N. oceanica for the first time. The engineered N. oceanica overexpressing DGAT2 resulted in enhanced neutral lipid accumulation and altered fatty Ivabradine HCl composition. Altogether, our findings demon

• The focus of this review is on the diacylglycerol

  2020-11-26

  

  The focus of this review is on the diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) enzymes, DGAT1 and DGAT2, that catalyze the esterification of a fatty acyl moiety to a DAG molecule to produce TAG. These enzymes commit DAG to being stored as TAG rather than being diverted for the synthesis of ph

• We examined the function of immobilised

  2020-11-26

  

  We examined the function of immobilised THPs by seeding cells transfected with DDR2-Flag on derivatised crosslinked collagen films, then detecting the phosphorylation of tyrosine 740 (Y740) on the intracellular domain of DDR2 [50]. This regulatory residue is a target for the intracellular tyrosine k

15240 records 688/1016 page Previous Next First page 上5页 686687688689690 下5页 Last page