• Many authors suggest that an increased production of ROS

  2018-10-31

  

  Many authors suggest that an increased production of ROS in the beginning of differentiation is an essential factor for adipogenesis (Liu et al., 2012; Zhou et al., 2014; Wang and Hai, 2015). ROS could, in small quantities, act in cell signaling (Mc Bride et al., 2006; Zhang and Gutterman, 2007) and

• Effective differentiation of hPSCs into DE is coupled with

  2018-10-31

  

  Effective differentiation of hPSCs into DE is coupled with the suppression of E-CADHERIN/CDH1 and pluripotency. Whereas BMP signaling has been reported to suppress E-CADHERIN/CDH1 and pluripotency (Teo et al., 2011, 2012), we observed that WNT3A is not as effective as GSK-3 inhibitors in suppressing

• Small molecules have demonstrated great potential in modulat

  2018-10-31

  

  Small molecules have demonstrated great potential in modulating cellular fate and functions. A milestone work showed that mouse iPSCs were successfully induced from mouse embryonic fibroblasts (MEF) via six chemical molecules, in the absence of Yamanaka reprogramming factors (Hou et al., 2013). Rece

• A recently developed gene editing technology

  2018-10-31

  

  A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

• These insights into the HSC independent versus HSC

  2018-10-31

  

  These insights into the HSC-independent versus HSC-dependent immune cell reconstitution pathway in mice can be expected to affect protocols used for HSC transplantation in clinical settings. Over the past 45 years, HSC transplantation has been widely used to treat patients with cancers such as leuk

• br Results br Discussion Analysis of DNA

  2018-10-31

  

  Results Discussion Analysis of DNA-damage foci in CHK1i-treated GSK503 led to the remarkable discovery that CHK1i allowed FA-deficient iPSCs to escape G2 arrest and undergo mitosis without repairing the DSBs that had evidently caused their arrest. A previous study indicates that DSBs arising

• These data are in agreement with

  2018-10-31

  

  These data are in agreement with prior studies demonstrating that hyaluronan levels play a critical role in determining the site of HSC lodgment/engraftment following transplantation (Avigdor et al., 2004; Ellis et al., 2007, 2009, 2011; Nilsson et al., 2003), and that HSC exhibit preferential engra

• The goal of this contribution is

  2018-10-30

  

  The goal of this contribution is to fill the existing gap in the structural studies. In the first stage, we have focused our attention on examining the features of the temperature evolution of the structure of the high-temperature phase of solid (1–x)Pb(Fe2/3W1/3O3)–(x)PbTiO3 solutions in the MPB re

• Table shows results from models partitioned by

  2018-10-30

  

  Table 4 shows results from models partitioned by sex. In nucleoside analog to the pooled results, Model 2 of Table 4, our fully adjusted model, shows no statistically significant difference in the probability of being a current smoker among the first generation males in the sample by age at migratio

• Laponite synthetic clay known as nanoclay consists of two te

  2018-10-30

  

  Laponite, synthetic clay, known as 2:1 nanoclay consists of two tetrahedral silicate sheets sandwiching an octahedral sheet and separated from another unit via electrostatic interaction. The geometrical structure is disk-like with diameter of ∼30nm and thickness of 1nm. Clays are used in biosensors

• In recent years studies in finance and

  2018-10-30

  

  In recent years studies in finance and in econometrics have tried to produce accurate forecasts of the term structure. Duffee (2002) uses the dynamic properties of affine models and concludes that his forecasts are dominated by the random walk model. The forecast underperformance of affine models st

• In innovation and technology diffusion literature R D expend

  2018-10-30

  

  In innovation and technology diffusion literature, R & D expenditures play a decisive role. R & D expenditures are considered as flows and measured by the R & D intensity, i.e., R & D expenditures divided by the product of the firm. Therefore, the R & D intensity is considered a measure of technolog

• Since the stability condition of

  2018-10-30

  

  Since σ∈(0, 1), the stability condition of the equilibrium capacity utilisation is s(1−α2)(1−σ)−α1>0. Given that u∈(0, 1), we must also assume g0>αsiλ2. Other things held constant, from Eq. (15), the partial effect of a change in the hbv virus interest rate, in the debt-capital ratio and in the wa

• br Materials and Methods br

  2018-10-30

  

  Materials and Methods Results Discussion Although measles is now a vaccine-preventable disease, measles remains one of the most important causes of child morbidity and mortality worldwide with the greatest burden in the youngest children (Moss and Griffin, 2006; Nandy et al., 2006; Wolfson

• We investigated whether a correlation may

  2018-10-30

  

  We investigated whether a correlation may exist between a positive qPCRgyrALp assay, the presence of gyrA83 mutations in respiratory samples and severe legionellosis evolution (Table 2). A trend was noted, albeit not significant, for more frequent admission to the ICU for patients with a positive qP

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