• A recently developed gene editing technology

  2018-10-31

  

  A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

• These insights into the HSC independent versus HSC

  2018-10-31

  

  These insights into the HSC-independent versus HSC-dependent immune cell reconstitution pathway in mice can be expected to affect protocols used for HSC transplantation in clinical settings. Over the past 45 years, HSC transplantation has been widely used to treat patients with cancers such as leuk

• br Results br Discussion Analysis of DNA

  2018-10-31

  

  Results Discussion Analysis of DNA-damage foci in CHK1i-treated GSK503 led to the remarkable discovery that CHK1i allowed FA-deficient iPSCs to escape G2 arrest and undergo mitosis without repairing the DSBs that had evidently caused their arrest. A previous study indicates that DSBs arising

• These data are in agreement with

  2018-10-31

  

  These data are in agreement with prior studies demonstrating that hyaluronan levels play a critical role in determining the site of HSC lodgment/engraftment following transplantation (Avigdor et al., 2004; Ellis et al., 2007, 2009, 2011; Nilsson et al., 2003), and that HSC exhibit preferential engra

• The goal of this contribution is

  2018-10-30

  

  The goal of this contribution is to fill the existing gap in the structural studies. In the first stage, we have focused our attention on examining the features of the temperature evolution of the structure of the high-temperature phase of solid (1–x)Pb(Fe2/3W1/3O3)–(x)PbTiO3 solutions in the MPB re

• Table shows results from models partitioned by

  2018-10-30

  

  Table 4 shows results from models partitioned by sex. In nucleoside analog to the pooled results, Model 2 of Table 4, our fully adjusted model, shows no statistically significant difference in the probability of being a current smoker among the first generation males in the sample by age at migratio

• Laponite synthetic clay known as nanoclay consists of two te

  2018-10-30

  

  Laponite, synthetic clay, known as 2:1 nanoclay consists of two tetrahedral silicate sheets sandwiching an octahedral sheet and separated from another unit via electrostatic interaction. The geometrical structure is disk-like with diameter of ∼30nm and thickness of 1nm. Clays are used in biosensors

• In recent years studies in finance and

  2018-10-30

  

  In recent years studies in finance and in econometrics have tried to produce accurate forecasts of the term structure. Duffee (2002) uses the dynamic properties of affine models and concludes that his forecasts are dominated by the random walk model. The forecast underperformance of affine models st

• In innovation and technology diffusion literature R D expend

  2018-10-30

  

  In innovation and technology diffusion literature, R & D expenditures play a decisive role. R & D expenditures are considered as flows and measured by the R & D intensity, i.e., R & D expenditures divided by the product of the firm. Therefore, the R & D intensity is considered a measure of technolog

• Since the stability condition of

  2018-10-30

  

  Since σ∈(0, 1), the stability condition of the equilibrium capacity utilisation is s(1−α2)(1−σ)−α1>0. Given that u∈(0, 1), we must also assume g0>αsiλ2. Other things held constant, from Eq. (15), the partial effect of a change in the hbv virus interest rate, in the debt-capital ratio and in the wa

• br Materials and Methods br

  2018-10-30

  

  Materials and Methods Results Discussion Although measles is now a vaccine-preventable disease, measles remains one of the most important causes of child morbidity and mortality worldwide with the greatest burden in the youngest children (Moss and Griffin, 2006; Nandy et al., 2006; Wolfson

• We investigated whether a correlation may

  2018-10-30

  

  We investigated whether a correlation may exist between a positive qPCRgyrALp assay, the presence of gyrA83 mutations in respiratory samples and severe legionellosis evolution (Table 2). A trend was noted, albeit not significant, for more frequent admission to the ICU for patients with a positive qP

• SUDEP genetics is an important area and we must acknowledge

  2018-10-30

  

  SUDEP purchase Asiaticoside is an important area, and we must acknowledge limitations to our study. The number of individuals who succumbed to SUDEP is small. Whilst there are new efforts to address this problem, to date case recognition and ascertainment (Smithson et al., 2014), collection of suita

• br Discussion Standard protocols of

  2018-10-30

  

  Discussion Standard protocols of the assessment of neuropathic pain have been widely agreed for specialist settings and primary care (Haanpää et al., 2011; Jones & Backonja, 2013). However, there is no common approach or consensus reached by clinicians or researchers to define neuropathic pain in

• Particulate matter was characterized in broncho alveolar lav

  2018-10-30

  

  Particulate matter was characterized in broncho-alveolar lavage fluid (BALF) extracts and in situ in AM of asthmatic Parisian children. Asthmatic patients, rather than healthy subjects, were selected for the study since fiber-optic bronchoscopy with broncho-alveolar lavage is routinely performed in

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