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To introduce in a simple way
2023-10-26
To introduce in a simple way the variability in the concentration of the proteins involved in the process, and to consider possible stochastic effects due to possible finite sizes of the populations involved in the problem, the dynamics of each cell is studied using the Gillespie’s algorithm (Gilles
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Unfortunately results of serum plasma AC assessment after
2023-10-26
Unfortunately, results of serum/plasma AC assessment after food antioxidant intake are rather controversial: although some papers reported an increase of AC after food antioxidant intake (Khan et al., 2015, Torabian et al., 2009), unexpectedly, in a lot of long-term intervention studies (days, weeks
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In order to further explore whether the cytoprotective effec
2023-10-26
In order to further explore whether the cytoprotective effect of isogarcinol against oxidative stress in H2O2-induced HepG2 8711 is a consequence of the breakdown of the endogenous antioxidant defence mechanism, we measured the LDH release, MDA levels, GSH levels and SOD activity. A large body of e
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br Future view and implications The selection and
2023-10-26
Future view and implications The selection and spread of multi(drug)-resistant microorganisms over the last decades has become a major and global public health concern [35]. Two growing threats originating from the fungal kingdom, i.e. Aspergillus fumigatus and Candida auris[36], [37], re-emphasi
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Discussion The present experiments follow up and are
2023-10-26
Discussion The present experiments follow-up and are completely consistent with our prior findings [26] that blood Aβ is subject to peripheral clearance by a major pathway for circulating pathogens in primates, immune adherence [30,31]. CR1-mediated erythrocyte immune adherence, as well as CR1-medi
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Our present result that week old PKA mice
2023-10-26
Our present result that ≤2-week-old 150ΔPKA mice express normal LTP that does not depend on CP-AMPARs also supports the collective findings of previous work showing that LTP mechanisms are remarkably adaptable in juvenile animals compared with adults. In particular, GluA1 knockout, S845A/S831A, and
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In conclusion we have produced some
2023-10-26
In conclusion, we have produced some highly potent inhibitors of P450 in comparison to the standard Bialaphos sodium salt KTZ. Also, due to the limited specificity of these compounds against lyase in comparison to the 17α-OHase component, these compounds would be expected to have a major impact on
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In conclusion we have produced some
2023-10-26
In conclusion, we have produced some highly potent inhibitors of P450 in comparison to the standard 2-NBDG KTZ. Also, due to the limited specificity of these compounds against lyase in comparison to the 17α-OHase component, these compounds would be expected to have a major impact on corticosteroid
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The knowledge on the structure of CYP including
2023-10-26
The knowledge on the structure of CYP17, including its active site, provides a rationale for understanding many mutations that are found in enzyme dysfunction in clinical disease as well as the enzyme's dual hydroxylase and lyase catalytic capabilities. This knowledge will assist rational drug desig
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Taniyama et al reported a female with infertility who
2023-10-26
Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of Rivaroxaban was initiated using dexamethasone to control adrenal P prod
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In conclusion we have designed and synthesized a series of
2023-10-26
In conclusion, we have designed and synthesized a series of 4-phenyl-thiazole analogues as potent ATX inhibitors. Total twenty-five compounds were synthesized and evaluated for their inhibitory activity on ATX using FS-3 and human plasma assays. Compound was found to be the most potent derivative p
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In the present study we sought
2023-10-25
In the present study we sought to decipher the role of ATP-citrate lyase and of the mitochondrial NADH-dependent Mae in the oleaginous yeast Y. lipolytica. Indeed, although this yeast is one of the major models for lipid metabolism, the function of these enzymes is still not clear. As the study of t
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Inflammations lead to the perturbation
2023-10-25
Inflammations lead to the perturbation of aromatase enzyme [112], which normally is responsible for a broad array of critical functions. Chemotherapy targets this enzyme, so this treatment option is never side-effect-free and not fully-effective. Therefore, the mankind should be careful so as not to
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A key function of the reference
2023-10-25
A key function of the reference AFST would be to detect fungal resistance, i.e. to determine which antifungal agents are likely to be clinically inactive [2]. To this end, the epidemiological cut-off value, defined as ‘the upper end of the wild-type (WT) or beginning of the non-wild-type (NWT) MIC d
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Furthermore a recently published network meta analysis inclu
2023-10-25
Furthermore, a recently published network meta-analysis including 30 trials in patients with hypertension and diabetes demonstrated that ARBs have efficacy similar to that of ACEIs for all-cause and cardiovascular mortality (HR 0.95, 95% CI 0.73 to 1.30 and HR 1.23, 95% CI 0.64 to 2.78, respectively
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