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Tension within the network could be explained by
2024-04-15
Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling igf 1 inhibitor filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin filame
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br Acknowledgement br Introduction There has been great
2024-04-15
Acknowledgement Introduction There has been great progress in the treatment of autoimmune disease during the past several decades. However, the majority of autoimmune diseases have no known cure. B lymphocytes and autoantibodies play important roles in many autoimmune diseases, including rheum
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Concerning asthma in a study evaluating the effect of
2024-04-15
Concerning asthma, in a study evaluating the effect of tiotropium in severe asthma, the sputum eosinophil count and exhaled nitric oxide were also assessed. However, evaluation of the anti-inflammatory effect of tiotropium was difficult because these markers were low at baseline and thereafter. In a
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br Methods and results ACE is a Canadian satellite mission
2024-04-15
Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric CA074 spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitudes but also provid
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sr9009 br Acknowledgements MC and PD were funded by the Mich
2024-04-15
Acknowledgements MC and PD were funded by the Michael J Fox Foundation (Grant ID 9969). We would like to thank Pierluigi Saba, Francesco Traccis and Barbara Tuveri for their technical assistance. Introduction In the prostate, androgens play a crucial role in normal, BPH and cancerous growth b
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1,2-Dilauroyl-sn-glycerol MafB a member of the Maf protein f
2024-04-15
MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in 1,2-Dilauroyl-sn-glycerol with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveola
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br Roles of apelin and APJ
2024-04-15
Roles of apelin and APJ in cardiovascular diseases Therapeutic potential of apelin/APJ in cardiovascular diseases Since the apelin/APJ system plays a key role in the occurrence and development of cardiovascular diseases, it seems logical to presume that targeting this axis should be feasible a
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br Acknowledgements This work was supported
2024-04-15
Acknowledgements This work was supported, in part, by NIH grant R01-GM071760. Introduction The MADS box genes encode a eukaryotic family of transcriptional regulators involved in diverse and important biological functions. This class of proteins has been identified in yeasts, plants, insects,
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br Diabetic retinopathy Diabetic retinopathy is a severe
2024-04-15
Diabetic retinopathy Diabetic retinopathy is a severe sight-threatening complication associated with diabetes mellitus. It is one of the most common causes of preventable blindness in the world. The risk of developing microvascular diabetic complications increases in diabetic patients with an inc
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Imatinib was first approved for the treatment
2024-04-13
Imatinib was first approved for the treatment of Philadelphia chromosome positive chronic myelogenous leukemia in 2001 [25]. This first approved small molecule antagonist is quite unusual in that it provides a durable response that lasts for more than a decade in the majority of patients. Imatinib h
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Overexpression of AR can lead to sorbitol accumulation leadi
2024-04-13
Overexpression of AR can lead to sorbitol accumulation, leading to diabetic complications (Ransohoff and Cardona, 2010). Therefore, AR is an important enzyme in the growth and development of organisms. With the aim of inhibiting the activity of AR in diabetic patients, screening for inhibitors and i
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Compound mg was purified as an amorphous colourless powder M
2024-04-13
Compound 3 (29 mg) was purified as an amorphous, colourless powder. Molecular formula C20H28O4 was established by HRESIMS (Fig. S11) and corroborated with 1H and 13C NMR spectroscopic data (Table 1). IR spectrum showed bands for hydroxyl (3433 cm−1) and carbonyl (1686 cm−1) groups. 13C NMR spectrum
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Casein accounts for of the total protein in bovine
2024-04-13
Casein accounts for 80% of the total protein in bovine milk (Capriotti, Cavaliere, Piovesana, Samperi, & Laganà, 2016); hydrolysates or bioactive peptides derived from casein have been employed widely in food as a functional ingredient (Capriotti et al., 2016, Field et al., 2008). Many studies have
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The synthetic route for the aminobenzoxazole scaffold with
2024-04-13
The synthetic route for the aminobenzoxazole scaffold with a solvent accessible moiety is described in . Nitration of methoxyphenol and subsequent hydrogenation of the resulting nitro BMH-21 afforded compound . Aminobenzoxazole was formed by the reaction of compound with BrCN in EtOH. The solvent
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Functional enhancers are often composed of binding motifs of
2024-04-13
Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge
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