br Conclusion Biotransformation of trachyloban oic acid by

Conclusion Biotransformation of trachyloban-19-oic Cobimetinib by S. racemosum provided three products. Oxidation of compound 1 at C-17 (2–3), as well as rearrangement of 1 into a kaurane diterpene hydroxylated in C-16 and C-17 (4) were crucial for increasing AChE inhibitory activity. Compound 3 was more active than galanthamine, commercial drug used for Alzheimer’s treatment. To the best of our knowledge, compounds 3 and 4 are herein described by the first time. The results emphasize the potential of these compounds as candidates for development of new drugs for Alzheimer’s disease.
Experimental
Acknowledgments The authors are nuclear area grateful to Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Ensino Superior (CAPES) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) for fellowships and financial support. We thank The United States Department of Agriculture – Agricultural Research Service for donation of S. racemosum NRRL 2496 strain.