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Although the exact mechanism by which
2018-11-08
Although the exact mechanism by which WNT3 levels in hESCs predict their differentiation potential is not known, we propose a working model that can explain all of our data so far (Figure 3C). It has been established that the identity of hESCs is mainly determined by the core pluripotency regulatory
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br Results and Discussion br Experimental Procedures br Ackn
2018-11-08
Results and Discussion Experimental Procedures Acknowledgments Introduction Insights into potential mechanisms for the regulation of mammalian tissue repair have come from studies of animals that can regenerate limbs, tails, and even the spinal cord, such as SAR 405 and reptiles. One ma
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Surgical transplantation Algvere et al
2018-11-08
Surgical transplantation (Algvere et al., 1997) or translocation (van Meurs and Van Den Biesen, 2003) of RPE sheets into the macula preserves central vision, providing proof of concept that RPE transplantation can be beneficial in AMD (reviewed in Binder et al., 2007). Stem cell technology now provi
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br Patients and methods br Introduction Embryonic stem
2018-11-08
Patients and methods Introduction Embryonic stem (ES) Sodium phosphate monobasic can give rise, in vivo, to the ectodermal, endodermal, and mesodermal germ layers and, in vitro, can differentiate into multiple cell lineages (Reubinoff et al., 2000; Wobus and Boheler, 2005). This ability to fo
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Genetically engineered stem cells may have an
2018-11-08
Genetically engineered stem cells may have an advantage for gene therapy due to their inherent migration to tumor sites (Kang et al., 2012a; Kang et al., 2012b; Kang et al., 2012d). In this study, we employed HB1.F3 human neural stem cells (hNSCs) obtained from 15week fetal telencephalon and immorta
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YZ9 br Cardiac niches and the
2018-11-08
Cardiac niches and the Notch receptor system The Notch pathway is an evolutionary conserved intercellular and intracellular mechanism that controls stem cell fate (Bray, 2006). The Notch gene family encodes transmembrane receptors that are activated by ligand binding and proteolytic cleavage, res
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UV induced changes in the cornea are largely mediated by
2018-11-08
UV-induced changes in the cornea are largely mediated by the up-regulation of pro-inflammatory cytokines such as interleukin (IL)1 (Corsini et al., 1997), IL6 (Di Girolamo et al., 2002), IL8 (Di Girolamo et al., 2002) and tumour necrosis factor alpha (TNFα) (Kennedy et al., 1997) which correlate to
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In the current study we compared two different genetic backg
2018-11-08
In the current study, we compared two different genetic backgrounds on the induction and maintenance of multipotency by generating clonal iNSC lines from two distinct mouse strains (C57BL/6 vs. C3H). Clonal iNSC lines from distinct genetic backgrounds exhibited the distinct levels of conversion effi
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br Experimental Procedures br Acknowledgments br Introductio
2018-11-08
Experimental Procedures Acknowledgments Introduction Hepatitis C virus (HCV) infects an estimated 2%–3% of the world population and is a major cause of liver disease and cancer. It is estimated that more than 350,000 people die of the HCV-related liver disease each year (Te and Jensen, 2010
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Caspase-3/7 Inhibitor manufacturer br Discussion In this stu
2018-11-08
Discussion In this study, we demonstrated the long-term in vitro maintenance and expansion of primary-sphere-derived CD24hi/CD29hi cells. These Caspase-3/7 Inhibitor manufacturer retained their ability to self-renew and remained fully functional upon transplantation. In addition to our in vivo e
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Most remarkably we identified Nppb Bnp a well
2018-11-08
Most remarkably, we identified Nppb (Bnp), a well-studied marker in cardiovascular disease, as a novel putative Shox2 target gene. This gene was analyzed as working myocard marker and turned out to be significantly upregulated in Shox2 SAN-like axl inhibitor and in right atrial tissue of Shox2-KO e
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If nestin cells do generate new neurons and DA neurons
2018-11-08
If nestin+cells do generate new neurons and DA neurons within the microenvironment of the adult midbrain, knowledge about their ontogenesis will be crucial to identify signaling mechanisms regulating neurogenesis and DA neurogenesis here, which might help progress cell-replacement therapies for PD.
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BMSCs are potential stem cells with the ability
2018-11-08
BMSCs are potential stem order cycloheximide solubility with the ability to differentiate into osteoblasts or adipocytes depending on the situation (Pittenger et al., 1999). Indeed, several molecules possess a role in regulating the differentiation of BMSCs (D\'Alimonte et al., 2013; Shui et al., 2
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Although the FDA considers analogous
2018-11-08
Although the FDA considers analogous cell product data an acceptable option for preclinical studies, it requires substantial similarity between analogous animal and human products (FDA, 2013). Due to the significant differences in the innate and adaptive immune system (Mestas and Hughes, 2004), hema
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br Conclusion This paper has
2018-11-07
Conclusion This paper has sought to illustrate some of the complexity of children\'s meaning-making with respect to health information by focussing upon the relationship between food and health. Looking through the lens of health literacy (and integrating ideas from New Literacy Studies) has help
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